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Article

RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis.

Journal of hepatology - 1 Sept 2023

Schaeffer Samantha, Gupta Barkha, Calatayud Anna-Line, Calderaro Julien, Caruso Stefano, Hirsch Théo Z, Pelletier Laura, Zucman-Rossi Jessica, Rebouissou Sandra

Abstract excerpt

BACKGROUND & AIMS: Recurrent somatic mutations of the RPS6KA3 gene encoding for the serine/threonine kinase RSK2 were identified in hepatocellular carcinomas (HCCs), suggesting its tumour-suppressive function. Our goal was to demonstrate the tumour suppressor role of RSK2 in the liver and investigate the functional consequences of its inactivation. METHODS: We analysed a series of 1,151 human HCCs for RSK2...

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Identifiers

PMID: 37201672
DOI: 10.1016/j.jhep.2023.05.004

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