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Article

Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.

PloS one - 1 Jan 2014

Churi Chaitanya R, Shroff Rachna, Wang Ying, Rashid Asif, Kang HyunSeon C, Weatherly Jacqueline, Zuo Mingxin, Zinner Ralph, Hong David, Meric-Bernstam Funda, Janku Filip, Crane Christopher H, Mishra Lopa, Vauthey Jean-Nicholas, Wolff Robert A, Mills Gordon, Javle Milind

Abstract excerpt

BACKGROUND: Cholangiocarcinoma (CCA) is clinically heterogeneous; intra and extrahepatic CCA have diverse clinical presentations. Next generation sequencing (NGS) technology may identify the genetic differences between these entities and identify molecular subgroups for targeted therapeutics. METHODS: We describe successful NGS-based testing of 75 CCA patients along with the prognostic and therapeutic...

Topics

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Bile Ducts, Intrahepatic
Cholangiocarcinoma
Demography
Disease-Free Survival
Genes, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Targeted Therapy

Oncogene Proteins, Fusion

Receptors, Fibroblast Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 25536104
DOI: 10.1371/journal.pone.0115383
PMCID: PMC4275227

Genes

IDH1
KRAS
ERBB2
PBRM1
BAP1
EGFR
MCL1
SMAD4

Provenance

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