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Genomic landscape of cholangiocarcinoma in India: ethnic variants and implications for targeted therapy.

BMC cancer - 20 Apr 2026

Suryavanshi Moushumi, Ostwal Vikas, Javle Milind, Kumar Manoj, Shetty Omshree, Patil Darshana, Sharma Shivani, Limaye Sewanti, Patel Amol, Sirohi Bhawna, Bahl Ankur, Rohtagi Nitesh

Abstract excerpt

BACKGROUND: Cholangiocarcinoma (CCA) is a molecularly heterogeneous malignancy of the biliary tract with rising global incidence and distinct geographic variations in oncogenic drivers. Despite India’s significant cancer burden, genomic data on CCA in Indian patients remain sparse, limiting the development of targeted therapies. METHODS: This retrospective, multi-institutional study analyzed molecular data from...

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Bile Duct Neoplasms
Cholangiocarcinoma
Class I Phosphatidylinositol 3-Kinases
Isocitrate Dehydrogenase
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Proteins

Ubiquitin Thiolesterase

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Identifiers

PMID: 42010540
DOI: 10.1186/s12885-026-15894-7
PMCID: PMC13104552

Genes

FGFR2
KRAS
TP53
IDH1
PIK3CA
BAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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