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Practical considerations in screening for genetic alterations in cholangiocarcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Sept 2021

Bekaii-Saab T S, Bridgewater J, Normanno N

Abstract excerpt

Cholangiocarcinoma (CCA) encompasses diverse epithelial tumors historically associated with poor outcomes due to an aggressive disease course, late diagnosis, and limited benefit of standard chemotherapy for advanced disease. Comprehensive molecular profiling has revealed a diverse landscape of genomic alterations as oncogenic drivers in CCA. TP53 mutations, CDKN2A/B loss, and KRAS mutations are the most common...

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Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Cholangiocarcinoma
Morpholines
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33932504
DOI: 10.1016/j.annonc.2021.04.012

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