Article
The amino acid variants in HLA II molecules explain the major association with adult-onset Still's disease in the Han Chinese population.
Journal of autoimmunity - 1 Jan 2021
Teng Jia-Lin, Chen Xia, Chen Jianhua, Zeng Ting, He Lin, Li Meihang, Luo Cai-Nan, Liu Shuang, Ding Ting-Ting, Yimaiti Kuerbanjiang, Li Xingwang, Ding Yonghe, Cheng Xiao-Bing, Zhou Juan, Ye Jun-Na, Ji Jue, Su Yu-Tong, Shi Hui, Sun Yue, Gao Chengwen, Hu Qiong-Yi, Chi Hui-Hui, Yuan Xuan, Zhou Zhuo-Chao, Wang Dong, Wang Ke, Feng Dong, Li Changgui, Sun Yuanchao, Niu Yujuan, Xu Xiaolei, Chen Lin-Jie, Xu Jian, Wu Li-Jun, Zhou Zhaowei, Pan Dun, Niu Haitao, Yang Cheng-de, Yongyong Shi, Li Zhiqiang, Liu Hong-Lei
Abstract excerpt
Adult-onset Still's disease (AOSD) is a rare autoinflammatory disease with systemic involvement, and its pathophysiology remains unclear. Genome-wide association studies (GWAS) in the Chinese population have revealed an association between AOSD and the major histocompatibility complex (MHC) locus; however, causal variants in the MHC remain undetermined. In the present study, we identified independent amino-acid...
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