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Article

The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease.

Immunology - 1 Aug 2017

Xie Li-Jun, Cui Zhao, Chen Fang-Jin, Pei Zhi-Yong, Hu Shui-Yi, Gu Qiu-Hua, Jia Xiao-Yu, Zhu Li, Zhou Xu-Jie, Zhang Hong, Liao Yun-Hua, Lai Lu-Hua, Hudson Billy G, Zhao Ming-Hui

Abstract excerpt

Goodpasture's disease is closely associated with HLA, particularly DRB1*1501. Other susceptible or protective HLA alleles are not clearly elucidated. The presentation models of epitopes by susceptible HLA alleles are also unclear. We genotyped 140 Chinese patients and 599 controls for four-digit HLA II genes, and extracted the encoding sequences from the IMGT/HLA database. T-cell epitopes of α3(IV)NC1 were...

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Identifiers

PMID: 28342268
DOI: 10.1111/imm.12736
PMCID: PMC5506429

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