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Article

FKBP5 variation is associated with the acute and chronic effects of nicotine.

The pharmacogenomics journal - 1 Aug 2015

Jensen K P, Herman A I, Morean M E, Kranzler H R, Gelernter J, Sofuoglu M

Abstract excerpt

Stress and hormones released in response to stress influence the effects of nicotine and the severity of nicotine withdrawal. Here, we systematically examine the contribution of a stress response gene, FKBP5, to the acute and chronic behavioral effects of nicotine in smokers. Subjects were European- and African-American (EA and AA) heavy smokers who participated in an intravenous (IV) nicotine administration...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25532758
DOI: 10.1038/tpj.2014.76
PMCID: PMC4599366

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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