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Article

FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2014

Huang Ming-Chyi, Schwandt Melanie L, Chester Julia A, Kirchhoff Aaron M, Kao Chung-Feng, Liang Tiebing, Tapocik Jenica D, Ramchandani Vijay A, George David T, Hodgkinson Colin A, Goldman David, Heilig Markus

Abstract excerpt

Alcohol withdrawal is associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The FKBP5 gene codes for a co-chaperone, FK506-binding protein 5, that exerts negative feedback on HPA axis function. This study aimed to examine the effects of single-nucleotide polymorphisms (SNPs) of the FKBP5 gene in humans and the effect of Fkbp5 gene deletion in mice on alcohol withdrawal severity. We genotyped six...

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Identifiers

PMID: 24603855
DOI: 10.1038/npp.2014.55
PMCID: PMC4059914

Genes

FKBP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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