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Article

FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2014

Huang Ming-Chyi, Schwandt Melanie L, Chester Julia A, Kirchhoff Aaron M, Kao Chung-Feng, Liang Tiebing, Tapocik Jenica D, Ramchandani Vijay A, George David T, Hodgkinson Colin A, Goldman David, Heilig Markus

Abstract excerpt

Alcohol withdrawal is associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The FKBP5 gene codes for a co-chaperone, FK506-binding protein 5, that exerts negative feedback on HPA axis function. This study aimed to examine the effects of single-nucleotide polymorphisms (SNPs) of t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24603855
DOI: 10.1038/npp.2014.55
PMCID: PMC4059914

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24603855-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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