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Article

Recombinant Marburg viruses containing mutations in the IID region of VP35 prevent inhibition of Host immune responses.

Virology - 1 Feb 2015

Albariño César G, Wiggleton Guerrero Lisa, Spengler Jessica R, Uebelhoer Luke S, Chakrabarti Ayan K, Nichol Stuart T, Towner Jonathan S

Abstract excerpt

Previous in vitro studies have demonstrated that Ebola and Marburg virus (EBOV and MARV) VP35 antagonize the host cell immune response. Moreover, specific mutations in the IFN inhibitory domain (IID) of EBOV and MARV VP35 that abrogate their interaction with virus-derived dsRNA, lack the ability to inhibit the host immune response. To investigate the role of MARV VP35 in the context of infectious virus, we used...

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Identifiers

PMID: 25531184
DOI: 10.1016/j.virol.2014.12.002
PMCID: PMC6461211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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