Article
The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR.
Journal of virology - 1 Jan 2007
Feng Zongdi, Cerveny Melissa, Yan Zhipeng, He Bin
Abstract excerpt
The VP35 protein of Ebola virus is a viral antagonist of interferon. It acts to block virus or double-stranded RNA-mediated activation of interferon regulatory factor 3, a transcription factor that facilitates the expression of interferon and interferon-stimulated genes. In this report, we show that the VP35 protein is also able to inhibit the antiviral response induced by alpha interferon. This depends on the...
Topics
- Animals
- Cells, Cultured
- Chlorocebus aethiops
- Ebolavirus
- Humans
- Interferon-alpha
- Interferon-beta
- Mice
- Mutation
- Phosphorylation
- RNA, Double-Stranded
- Sequence Analysis, Protein
- Vero Cells
- Viral Proteins
- Viral Regulatory and Accessory Proteins
- Virus Replication
- eIF-2 Kinase