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The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencing

21 Jun 2017

Abstract excerpt

Ebola virus and Marburg virus are members of the Filovirdae family and causative agents of hemorrhagic fever with high fatality rates in humans.Filovirus virulence is partially attributed to the VP35 protein, a well-characterized inhibitor of the RIG-I-like receptor pathway that triggers the antiviral interferon (IFN) response.Prior work demonstrates the ability of VP35 to block potent RIG-I activators, such as...

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PMID: 28636653
DOI: 10.1371/journal.pone.0178717

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