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Article

Inhibition of IRF-3 Activation by VP35 Is Critical for the High Level of Virulence of Ebola Virus

17 Jan 2008

Abstract excerpt

Zaire ebolavirus causes a rapidly progressing hemorrhagic disease with high mortality. Identification of the viral virulence factors that contribute to the severity of disease induced by Ebola virus is critical for the design of therapeutics and vaccines against the disease. Given the rapidity of disease progression, virus interaction with the innate immune system early in the course of infection likely plays an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18199658
DOI: 10.1128/jvi.02344-07

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Inhibition of IRF-3 Activation by VP35 Is Critical for the High Level of Virulence of Ebola VirusPMID 18199658Read ↗

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