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Article

Structural basis for Marburg virus VP35–mediated immune evasion mechanisms

26 Nov 2012

Abstract excerpt

Filoviruses, marburgvirus (MARV) and ebolavirus (EBOV), are causative agents of highly lethal hemorrhagic fever in humans. MARV and EBOV share a common genome organization but show important differences in replication complex formation, cell entry, host tropism, transcriptional regulation, and immune evasion. Multifunctional filoviral viral protein (VP) 35 proteins inhibit innate immune responses. Recent studies...

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PMID: 23185024
DOI: 10.1073/pnas.1213559109

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