Article
Quality improvement of mitochondrial respiratory chain complex enzyme assays using Caenorhabditis elegans.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2011
Chen Xiulian, Thorburn David R, Wong Lee-Jun, Vladutiu Georgirene D, Haas Richard H, Le Thuy, Hoppel Charles, Sedensky Margaret, Morgan Philip, Hahn Si Houn
Abstract excerpt
PURPOSE: The diagnosis of a mitochondrial disorder relies heavily on the enzymatic analysis of mitochondrial respiratory chain complexes in muscle or other tissues. However, considerable differences exist between clinical laboratories in the protocols or particular tests used for evaluation. In addition, laboratories can encounter difficulties in consistent technique, as well as procurement of adequate positive...
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