Article
The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine - 15 Dec 2013
O'Dwyer David N, Armstrong Michelle E, Trujillo Glenda, Cooke Gordon, Keane Michael P, Fallon Padraic G, Simpson A John, Millar Ann B, McGrath Emmet E, Whyte Moira K, Hirani Nik, Hogaboam Cory M, Donnelly Seamas C
Abstract excerpt
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a fatal progressive interstitial pneumonia. The innate immune system provides a crucial function in the recognition of tissue injury and infection. Toll-like receptor 3 (TLR3) is an innate immune system receptor. We investigated the role of a functional TLR3 single-nucleotide polymorphism in IPF. OBJECTIVES: To characterize the effects of the TLR3 Leu412Phe...
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