Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Profile of differential promoter activity by nucleotide substitution at GWAS signals for multiple sclerosis.

Medicine - 1 Dec 2014

Ryu Jihye, Woo Jeyoung, Shin Jimin, Ryoo Hyunju, Kim Younyoung, Lee Chaeyoung

Abstract excerpt

This experimental study was conducted with completely randomized design. Genome-wide association studies (GWAS) have revealed a large number of genetic associations of nucleotide sequence variants with susceptibility to multiple sclerosis (MS). Nevertheless, studies to identify the functional relevance of these variants lag far behind identification of the GWAS signals. Expression quantitative trait loci (eQTLs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cells, Cultured
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genome-Wide Association Study

Share to Multiple Sclerosis

Share to Nucleotides

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 25526461
DOI: 10.1097/MD.0000000000000281
PMCID: PMC4603103

Genes

PVR
RGS14
SYK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Profile of differential promoter activity by nucleotide substitution at GWAS signals for multiple sclerosis.PMID 25526461Read ↗

Differential promoter activity by nucleotide substitution at a type 2 diabetes genome-wide association study signal upstream of the wolframin gene.Semantic proximity Read ↗

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients.Semantic proximity Read ↗

Genome-wide discovery of multiple sclerosis genetic risk variant allelic regulatory activity.Semantic proximity Read ↗

SNP@Promoter: a database of human SNPs (single nucleotide polymorphisms) within the putative promoter regions.Semantic proximity Read ↗

The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.Semantic proximity Read ↗

Potential regulatory SNPs in promoters of human genes: a systematic approach.Semantic proximity Read ↗

Contributions of vitamin D response elements and HLA promoters to multiple sclerosis risk.Semantic proximity Read ↗

dbQSNP: a database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism-based methods.Semantic proximity Read ↗

Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing.Semantic proximity Read ↗

Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.Semantic proximity Read ↗

Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis.Semantic proximity Read ↗

Significant Association of rs77493513 Polymorphism in 3'-UTR of the NRG1 Gene with the Risk of Multiple Sclerosis Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.