The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.

doi:10.1177/1352458515610208

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The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jul 2016

Karaky Mohamad, Alcina Antonio, Fedetz María, Barrionuevo Cristina, Potenciano Victor, Delgado Concepción, Izquierdo Guillermo, Matesanz Fuencisla

Abstract excerpt

BACKGROUND: Vitamin D deficit is considered an important risk factor for many inflammatory and autoimmune diseases. OBJECTIVE: To investigate the influence of the multiple sclerosis (MS)-associated regulatory variant rs10877013 on the expression of genes involved in vitamin D activation (CYP27B1), vitamin D receptor (VDR), and vitamin D degradation (CYP24A1) under inflammatory environment or vitamin D. METHODS:...

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PMID: 26466946
DOI: 10.1177/1352458515610208

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