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Article

Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing.

Frontiers in immunology - 1 Jan 2022

Putscher Elena, Hecker Michael, Fitzner Brit, Boxberger Nina, Schwartz Margit, Koczan Dirk, Lorenz Peter, Zettl Uwe Klaus

Abstract excerpt

Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system to which a genetic predisposition contributes. Over 200 genetic regions have been associated with increased disease risk, but the disease-causing variants and their functional impact at the molecular level are mostly poorly defined. We hypothesized that single-nucleotide polymorphisms (SNPs) have an impact on...

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Identifiers

PMID: 36405756
DOI: 10.3389/fimmu.2022.931831
PMCID: PMC9670805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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