Article
A novel method for identifying SNP disease association based on maximal information coefficient.
Genetics and molecular research : GMR - 19 Dec 2014
Liu H M, Rao N, Yang D, Yang L, Li Y, Ou F
Abstract excerpt
To improve single-nucleotide polymorphism (SNP) association studies, we developed a method referred to as maximal information coefficient (MIC)-based SNP searching (MICSNPs) by employing a novel statistical approach known as the MIC to identify SNP disease associations. MIC values varied with minor allele frequencies of SNPs and the odds ratios for disease. We used a Monte Carlo-based permutation test to...
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