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Article

Large-scale multiple testing in genome-wide association studies via region-specific hidden Markov models.

BMC bioinformatics - 25 Sept 2013

Xiao Jian, Zhu Wensheng, Guo Jianhua

Abstract excerpt

BACKGROUND: Identifying genetic variants associated with complex human diseases is a great challenge in genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) arising from genetic background are often dependent. The existing methods, i.e., local index of significance (LIS) and pooled local index of significance (PLIS), were both proposed for modeling SNP dependence and assumed that the...

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Identifiers

PMID: 24067069
DOI: 10.1186/1471-2105-14-282
PMCID: PMC3850654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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