Article
Membrane fluidity alterations in a cytochrome P-450-deficient mutant of Candida albicans.
Steroids - 1 Jan 2000
Lees N D, Kleinhans F W, Broughton M C, Pennington D E, Ricker V A, Bard M
Abstract excerpt
A cytochrome P450-deficient mutant of the pathogenic fungus, Candida albicans, which accumulates exclusively 14 alpha-methylsterols in place of the normal end product sterol, ergosterol, was examined for alterations in membrane fluidity by electron paramagnetic resonance. The results using four n...
Topics
- Animals
- Antifungal Agents
- Azoles
- Candida albicans
- Cytochrome P-450 Enzyme System
- Electron Spin Resonance Spectroscopy
- Ergosterol
- Membrane Fluidity
- Mutation
- Sterols
- Viscosity