Article
Membrane fluidity alterations in a cytochrome P-450-deficient mutant of Candida albicans.
Steroids - 1 Jan 2000
Lees N D, Kleinhans F W, Broughton M C, Pennington D E, Ricker V A, Bard M
Abstract excerpt
A cytochrome P450-deficient mutant of the pathogenic fungus, Candida albicans, which accumulates exclusively 14 alpha-methylsterols in place of the normal end product sterol, ergosterol, was examined for alterations in membrane fluidity by electron paramagnetic resonance. The results using four nitroxyl spin labels indicated that exponential phase cultures of the mutant strain, D10, had a uniformly more rigid...
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