Article
The yeast plasma membrane proton pumping ATPase is a viable antifungal target. I. Effects of the cysteine-modifying reagent omeprazole.
Biochimica et biophysica acta - 4 Oct 1995
Monk B C, Mason A B, Abramochkin G, Haber J E, Seto-Young D, Perlin D S
Abstract excerpt
The yeast plasma membrane proton pumping ATPase (H(+)-ATPase) was investigated as a potential molecular target for antifungal drug therapy by examining the inhibitory effects of the sulfhydryl-reactive reagent omeprazole on cell growth, glucose-induced medium acidification and H(+)-ATPase activit...
Topics
- Candida albicans
- Cell Membrane
- Cysteine
- Enzyme Inhibitors
- Glucose
- Humans
- Hydrogen-Ion Concentration
- Kinetics
- Mercaptoethanol
- Mutation
- Omeprazole
- Proton Pump Inhibitors
- Proton Pumps
- Proton-Translocating ATPases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sulfhydryl Reagents