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Article

Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicans.

Antimicrobial agents and chemotherapy - 1 May 1990

Lees N D, Broughton M C, Sanglard D, Bard M

Abstract excerpt

A cytochrome P-450-deficient mutant of Candida albicans, strain D10, was employed to study the mode of action of imidazole antifungal agents. This mutant accumulates exclusively 14-alpha-methylsterols, resulting in a sterol profile which mimics that of azole-treated wild-type strains. Since the widely accepted primary effect of imidazoles is the inhibition of cytochrome P-450-mediated demethylation of the...

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Identifiers

PMID: 2193620
DOI: 10.1128/AAC.34.5.831
PMCID: PMC171701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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