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Article

Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicans.

Antimicrobial agents and chemotherapy - 1 May 1990

Lees N D, Broughton M C, Sanglard D, Bard M

Abstract excerpt

A cytochrome P-450-deficient mutant of Candida albicans, strain D10, was employed to study the mode of action of imidazole antifungal agents. This mutant accumulates exclusively 14-alpha-methylsterols, resulting in a sterol profile which mimics that of azole-treated wild-type strains. Since the w...

Topics

Azoles
Candida albicans
Clotrimazole
Cytochrome P-450 Enzyme System
Imidazoles
Ketoconazole
Miconazole
Microbial Sensitivity Tests
Mutation
Nystatin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2193620
DOI: 10.1128/AAC.34.5.831
PMCID: PMC171701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2193620-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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