Article
Changes in the cellular composition of Candida albicans resistant to miconazole.
Indian journal of biochemistry & biophysics - 1 Oct 1996
Sharma S, Khuller G K
Abstract excerpt
Biochemical changes that accompany acquisition of miconazole resistance in a single step mutant of C. albicans 3153 were analyzed. Experiments show that resistance to this drug was associated with decrease in total lipids, phospholipids and sterol content. Fluorescence polarization studies with 1,6-diphenyl-1,3,5-hexatriene (DPH) showed decrease in polarization value (p) in resistant cells, thus indicating...
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