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Article

Cholesterol Modulation Attenuates the AD-like Phenotype Induced by Herpes Simplex Virus Type 1 Infection.

Biomolecules - 20 May 2024

Salgado Blanca, Izquierdo Beatriz, Zapata Alba, Sastre Isabel, Kristen Henrike, Terreros Julia, Mejías Víctor, Bullido María J, Aldudo Jesús

Abstract excerpt

Cholesterol, a crucial component of cell membranes, influences various biological processes, including membrane trafficking, signal transduction, and host-pathogen interactions. Disruptions in cholesterol homeostasis have been linked to congenital and acquired conditions, including neurodegenerative disorders such as Alzheimer's disease (AD). Previous research from our group has demonstrated that herpes simplex...

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PMID: 38786010
DOI: 10.3390/biom14050603
PMCID: PMC11117519

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