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Article

Ectopic Recombination of a Malaria var Gene during Mitosis Associated with an Altered var Switch Rate

22 Apr 2009

Abstract excerpt

The Plasmodium falciparum var multigene family encodes P. falciparum erythrocyte membrane protein 1, which is responsible for the pathogenic traits of antigenic variation and adhesion of infected erythrocytes to host receptors during malaria infection. Clonal antigenic variation of P. falciparum erythrocyte membrane protein 1 is controlled by the switching between exclusively transcribed var genes. The tremendous...

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PMID: 19389407
DOI: 10.1016/j.jmb.2009.04.032

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