Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A neuroprotective function of NSF1 sustains autophagy and lysosomal trafficking in Drosophila.

Genetics - 1 Feb 2015

Babcock Daniel T, Shen Wei, Ganetzky Barry

Abstract excerpt

A common feature of many neurodegenerative diseases is the accumulation of toxic proteins that disrupt vital cellular functions. Degradative pathways such as autophagy play an important protective role in breaking down misfolded and long-lived proteins. Neurons are particularly vulnerable to defects in these pathways, but many of the details regarding the link between autophagy and neurodegeneration remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Dopaminergic Neurons
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Locomotion

Share to Longevity

Share to Lysosomes

Share to Protein Transport

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 25519897
DOI: 10.1534/genetics.114.172403
PMCID: PMC4317658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A neuroprotective function of NSF1 sustains autophagy and lysosomal trafficking in Drosophila.PMID 25519897Read ↗

Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis.Semantic proximity Read ↗

Genetic modifiers of comatose mutations in Drosophila: insights into neuronal NSF (N-ethylmaleimide-sensitive fusion factor) functions.Semantic proximity Read ↗

Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony.Semantic proximity Read ↗

Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter release.Semantic proximity Read ↗

Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae.Semantic proximity Read ↗

Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses.Semantic proximity Read ↗

Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila.Semantic proximity Read ↗

Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis.Semantic proximity Read ↗

ESCRTs and Fab1 regulate distinct steps of autophagy.Semantic proximity Read ↗

Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1.Semantic proximity Read ↗

Genetic interaction between shibire and comatose mutations in Drosophila suggest a role for snap-receptor complex assembly and disassembly for maintenance of synaptic vesicle cycling.Semantic proximity Read ↗

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.