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Article

Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis.

Journal of neurochemistry - 1 Jun 2001

Mohtashami M, Stewart B A, Boulianne G L, Trimble W S

Abstract excerpt

NEM-sensitive fusion protein (NSF) is an ATPase required for many intracellular membrane trafficking steps. Recent studies have suggested that NSF alters the conformation of the SNAP receptors (SNAREs) to permit their interaction, or to uncouple them after they interact. Most organisms have a sin...

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Source

Identifiers

PMID: 11389191
DOI: 10.1046/j.1471-4159.2001.00363.x

Genes

NSF
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11389191-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis.PMID 11389191Read ↗

Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter release.Semantic proximity Read ↗

Genetic modifiers of comatose mutations in Drosophila: insights into neuronal NSF (N-ethylmaleimide-sensitive fusion factor) functions.Semantic proximity Read ↗

Genetic interaction between shibire and comatose mutations in Drosophila suggest a role for snap-receptor complex assembly and disassembly for maintenance of synaptic vesicle cycling.Semantic proximity Read ↗

Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony.Semantic proximity Read ↗

A neuroprotective function of NSF1 sustains autophagy and lysosomal trafficking in Drosophila.Semantic proximity Read ↗

NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.Semantic proximity Read ↗

Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses.Semantic proximity Read ↗

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.Semantic proximity Read ↗

Phenotypic interaction between temperature-sensitive paralytic mutants comatose and paralytic suggests a role for N-ethylmaleimide-sensitive fusion factor in synaptic vesicle cycling in Drosophila.Semantic proximity Read ↗

Activity-dependent interactions of NSF and SNAP at living synapses.Semantic proximity Read ↗

Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis.Semantic proximity Read ↗

Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.Semantic proximity Read ↗

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