Article
Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae.
Fly - 1 Jan 2000
Aby Elizabeth, Gumps Katherine, Roth Amalia, Sigmon Stacey, Jenkins Sarah E, Kim Joyce J, Kramer Nicholas J, Parfitt Karen D, Korey Christopher A
Abstract excerpt
Infantile-onset neuronal ceroid lipofuscinosis (INCL) is a severe pediatric neurodegenerative disorder produced by mutations in the gene encoding palmitoyl-protein thioesterase 1 (Ppt1). This enzyme is responsible for the removal of a palmitate group from its substrate proteins, which may include presynaptic proteins like SNAP-25, cysteine string protein (CSP), dynamin, and synaptotagmin. The fruit fly,...
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