Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity.

Biochimica et biophysica acta - 4 Aug 2004

Rached Mohamed, Buronfosse Anna, Begeot Martine, Penhoat Armelle

Abstract excerpt

Melanocortins are known to be involved in the regulation of feeding behavior. These hormones mediate their effects through G protein-coupled receptors (GPCRs) by stimulating adenylate cyclase. The melanocortin 3 receptor (MC3R) in the melanocortin receptor (MCR) family has been identified as a neural receptor subtype mainly expressed in the brain in mammals. Until now, only one heterozygous mutation (I183N) has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to Cyclic AMP

Share to DNA Primers

Share to Microscopy, Electron

Share to Obesity

Share to Receptor, Melanocortin, Type 3

Source

Identifiers

PMID: 15276649
DOI: 10.1016/j.bbadis.2004.03.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity.PMID 15276649Read ↗

Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.Semantic proximity Read ↗

Mutations in Melanocortin-3 Receptor Gene and Human Obesity.Semantic proximity Read ↗

Functions of transmembrane domain 3 of human melanocortin-4 receptor.Semantic proximity Read ↗

Identification and functional characterization of novel mutations in the melanocortin-4 receptor.Semantic proximity Read ↗

Functional characterization of nine novel naturally occurring human melanocortin-3 receptor mutations.Semantic proximity Read ↗

Identification and characterization of two novel melanocortin-3 receptor mutations in Chinese obese individuals.Semantic proximity Read ↗

A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity.Semantic proximity Read ↗

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients.Semantic proximity Read ↗

Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.Semantic proximity Read ↗

Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.Semantic proximity Read ↗

Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity.Semantic proximity Read ↗

A Novel Loss of Function Melanocortin-4-Receptor Mutation (MC4R-F313Sfs*29) in Morbid Obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.