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Article

Genetic predictor of working memory and prefrontal function in women with HIV.

Journal of neurovirology - 1 Feb 2015

Sundermann Erin E, Bishop Jeffrey R, Rubin Leah H, Little Deborah M, Meyer Vanessa J, Martin Eileen, Weber Kathleen, Cohen Mardge, Maki Pauline M

Abstract excerpt

The Val158Met (rs4680) single-nucleotide polymorphism (SNP) of the catechol-O-methyltransferase gene (COMT) influences executive function and prefrontal function through its effect on dopamine (DA) metabolism. Both HIV and the Val allele of the Val158Met SNP are associated with compromised execut...

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Source

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Identifiers

PMID: 25515329
DOI: 10.1007/s13365-014-0305-z
PMCID: PMC4319991

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25515329-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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