Article
Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2015
Brown Tyler S, Jacob Christopher G, Silva Joana C, Takala-Harrison Shannon, Djimdé Abdoulaye, Dondorp Arjen M, Fukuda Mark, Noedl Harald, Nyunt Myaing Myaing, Kyaw Myat Phone, Mayxay Mayfong, Hien Tran Tinh, Plowe Christopher V, Cummings Michael P
Abstract excerpt
Multiple transcontinental waves of drug resistance in Plasmodium falciparum have originated in Southeast Asia before spreading westward, first into the rest of Asia and then to sub-Saharan Africa. In vitro studies have suggested that hypermutator P. falciparum parasites may exist in Southeast Asia and that an increased rate of acquisition of new mutations in these parasites may explain the repeated emergence of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.