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Article

Tumor-suppressor role of Notch3 in medullary thyroid carcinoma revealed by genetic and pharmacological induction.

Molecular cancer therapeutics - 1 Feb 2015

Jaskula-Sztul Renata, Eide Jacob, Tesfazghi Sara, Dammalapati Ajitha, Harrison April D, Yu Xiao-Min, Scheinebeck Casi, Winston-McPherson Gabrielle, Kupcho Kevin R, Robers Matthew B, Hundal Amrit K, Tang Weiping, Chen Herbert

Abstract excerpt

Notch1-3 are transmembrane receptors that appear to be absent in medullary thyroid cancer (MTC). Previous research has shown that induction of Notch1 has a tumor-suppressor effect in MTC cell lines, but little is known about the biologic consequences of Notch3 activation for the progression of the disease. We elucidate the role of Notch3 in MTC by genetic (doxycycline-inducible Notch3 intracellular domain) and...

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Source

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Identifiers

PMID: 25512616
DOI: 10.1158/1535-7163.MCT-14-0073
PMCID: PMC4326595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tumor-suppressor role of Notch3 in medullary thyroid carcinoma revealed by genetic and pharmacological induction.PMID 25512616Read ↗

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