Article
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010
Mazzone Marco, Selfors Laura M, Albeck John, Overholtzer Michael, Sale Sanja, Carroll Danielle L, Pandya Darshan, Lu Yiling, Mills Gordon B, Aster Jon C, Artavanis-Tsakonas Spyros, Brugge Joan S
Abstract excerpt
Aberrant activation of Notch receptors has been implicated in breast cancer; however, the mechanisms contributing to Notch-dependent transformation remain elusive because Notch displays dichotomous functional activities, promoting both proliferation and growth arrest. We investigated the cellular basis for the heterogeneous responses to Notch pathway activation in 3D cultures of MCF-10A mammary epithelial cells....
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