Article
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010
Mazzone Marco, Selfors Laura M, Albeck John, Overholtzer Michael, Sale Sanja, Carroll Danielle L, Pandya Darshan, Lu Yiling, Mills Gordon B, Aster Jon C, Artavanis-Tsakonas Spyros, Brugge Joan S
Abstract excerpt
Aberrant activation of Notch receptors has been implicated in breast cancer; however, the mechanisms contributing to Notch-dependent transformation remain elusive because Notch displays dichotomous functional activities, promoting both proliferation and growth arrest. We investigated the cellular...
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