Article
Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line.
Cancer medicine - 1 Oct 2013
Tesfazghi Sara, Eide Jacob, Dammalapati Ajitha, Korlesky Colin, Wyche Thomas P, Bugni Tim S, Chen Herbert, Jaskula-Sztul Renata
Abstract excerpt
Medullary thyroid cancer (MTC) is an aggressive neuroendocrine tumor (NET). Previous research has shown that activation of Notch signaling has a tumor suppressor role in NETs. The potential therapeutic effect of thiocoraline on the activation of the Notch pathway in an MTC cell line (TT) was investigated. Thiocoraline was isolated from a marine bacterium Verrucosispora sp. MTT assay (3-[4,...
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