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Article

Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line.

Cancer medicine - 1 Oct 2013

Tesfazghi Sara, Eide Jacob, Dammalapati Ajitha, Korlesky Colin, Wyche Thomas P, Bugni Tim S, Chen Herbert, Jaskula-Sztul Renata

Abstract excerpt

Medullary thyroid cancer (MTC) is an aggressive neuroendocrine tumor (NET). Previous research has shown that activation of Notch signaling has a tumor suppressor role in NETs. The potential therapeutic effect of thiocoraline on the activation of the Notch pathway in an MTC cell line (TT) was inve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24403239
DOI: 10.1002/cam4.118
PMCID: PMC3892805

Genes

ASCL1
HES1
HES2
HES6
HEY1
HEY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24403239-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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