Article
Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma.
Oncotarget - 15 Nov 2014
Giovannini Catia, Minguzzi Manuela, Baglioni Michele, Fornari Francesca, Giannone Ferdinando, Ravaioli Matteo, Cescon Matteo, Chieco Pasquale, Bolondi Luigi, Gramantieri Laura
Abstract excerpt
To successfully target Notch receptors as part of a multidrug anticancer strategy, it will be essential to fully characterize the factors that are modulated by Notch signaling. We recently reported that Notch3 silencing in HCC results in p53 up-regulation in vitro and, therefore, we focused on the mechanisms that associate Notch3 to p53 protein expression. We explored the regulation of p53 by Notch3 signalling in...
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