Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells.

The Journal of biological chemistry - 29 Dec 2006

Kunnimalaiyaan Muthusamy, Vaccaro Abram M, Ndiaye Mary A, Chen Herbert

Abstract excerpt

The role of NOTCH1 as an oncogene or tumor suppressor appears to be cell type-specific. Medullary thyroid cancer (MTC) cells characteristically express the transcription factor ASCL1 (achaete-scute complex-like 1) as well as high levels of the neuroendocrine (NE) markers calcitonin and chromogran...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Medullary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Growth Inhibitors

Share to Intracellular Space

Share to Neurosecretory Systems

Share to Receptor, Notch1

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 17090547
DOI: 10.1074/jbc.M603578200

Genes

NOTCH1
ASCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17090547-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells.PMID 17090547Read ↗

Notch Signaling Is Involved in Expression of Thyrocyte Differentiation Markers and Is Down-Regulated in Thyroid TumorsSemantic proximity Read ↗

Tumor-suppressor role of Notch3 in medullary thyroid carcinoma revealed by genetic and pharmacological induction.Semantic proximity Read ↗

Thyroid C-Cell Biology and Oncogenic Transformation.Semantic proximity Read ↗

The role of human achaete-scute homolog-1 in medullary thyroid cancer cells.Semantic proximity Read ↗

Thyroid C-Cell Biology and Oncogenic Transformation.Semantic proximity Read ↗

Clinical and pathological analysis of 19 cases of medullary thyroid carcinoma without an increase in calcitonin.Semantic proximity Read ↗

Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells.Semantic proximity Read ↗

Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line.Semantic proximity Read ↗

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.Semantic proximity Read ↗

Upregulated JAG1 Enhances Cell Proliferation in Adrenocortical CarcinomaSemantic proximity Read ↗

The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.Semantic proximity Read ↗

Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.