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Mechanisms of resistance to NAMPT inhibitors in cancer

16 Apr 2025

Abstract excerpt

A common barrier to the development of effective anticancer agents is the development of drug resistance. This obstacle remains a challenge to successful clinical translation, particularly for targeted agents. Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors represent a clinically applicable drug class that exploits the increased dependence of cancer cells on nicotinamide adenine dinucleotide (NAD+), a...

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PMID: 40342733
DOI: 10.20517/cdr.2024.216

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