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Article

Rubicon deficiency enhances cardiac autophagy and protects mice from lipopolysaccharide-induced lethality and reduction in stroke volume.

Journal of cardiovascular pharmacology - 1 Mar 2015

Zi Zhenguo, Song Zongpei, Zhang Shasha, Ye Yong, Li Can, Xu Mingqing, Zou Yunzeng, He Lin, Zhu Hongxin

Abstract excerpt

: Rubicon has been suggested to suppress autophagosome maturation by negatively regulating PI3KC3/Vps34 activity. However, the physiological function of Rubicon remains elusive. We hypothesized that Rubicon deficiency enhances autophagic flux in the heart and affects cardiac function. Rubicon knockout (KO) mice were generated by piggyBac transposition. Loss of Rubicon was demonstrated at both mRNA and protein...

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Source

Identifiers

PMID: 25502307
DOI: 10.1097/FJC.0000000000000188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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