Article
Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction.
Cell research - 1 Aug 2015
Jia Xiao-E, Ma Ke, Xu Tao, Gao Lei, Wu Shuang, Fu Cong, Zhang Wenjuan, Wang Zhizhang, Liu Kaiyu, Dong Mei, Jing Changbin, Ren Chunguang, Dong Zhiwei, Chen Yi, Jin Yi, Huang Qiuhua, Chang Xing, Deng Min, Li Li, Luo Lingfei, Zhu Jun, Dang Yongjun, Chang Hung-Chun, Zon Leonard I, Zhou Yi, Chen Saijuan, Pan Weijun
Abstract excerpt
Dysregulation of ribosome biogenesis causes human diseases, such as Diamond-Blackfan anemia, del (5q-) syndrome and bone marrow failure. However, the mechanisms of blood disorders in these diseases remain elusive. Through genetic mapping, molecular cloning and mechanism characterization of the zebrafish mutant cas002, we reveal a novel connection between ribosomal dysfunction and excessive autophagy in the...
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