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Article

Essential role for UVRAG in autophagy and maintenance of cardiac function

30 Sept 2013

Abstract excerpt

AIMS: Ultraviolet irradiation resistance-associated gene (UVRAG) is a tumour suppressor candidate that regulates cell autophagy and endocytosis. However, the in vivo function of UVRAG remains poorly understood. We sought to determine the physiological role of UVRAG in the heart. METHODS AND RESULTS: We characterized mice with disruption of the UVRAG gene by piggyBac (PB) transposon insertion. PB construct was...

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PMID: 24081163
DOI: 10.1093/cvr/cvt223

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