Article

Peptide: N-Glycanase 1 and Its Relationship with Congenital Disorder of Deglycosylation

2022-03-10

Abstract excerpt

The cytosolic PNGase (peptide:N-glycanase; Png1 in yeast; NGLY1/Ngly1 in human/mice), also known as peptide-N4-(N-acetyl-beta-glucosaminyl)-asparagine ami-dase, is a well-conserved deglycosylation enzyme (EC 3.5.1.52) which catalyzes the non-lysosomal hydrolysis of an N(4)-(acetyl-β-D-glucosaminyl) asparagine residue into N-acetyl-β-D-glucosaminylamine and a peptide containing an aspartate residue. This...

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Literature Corpus work: 5d4a776c-28a0-58b7-9e47-21626ed39afc
DOI: 10.20944/preprints202203.0148.v1

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