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Article

SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors

13 Dec 2014

Abstract excerpt

The epithelial to mesenchymal transition (EMT) is an essential process during development and during tumor progression. Here, we observed the accumulation of the selective autophagy receptor and signaling adaptor sequestosome-1 (SQSTM1/p62) during growth factor-induced EMT in immortalized and tumor-derived epithelial cell lines. Modulation of the p62 level regulated the expression of junctional proteins. This...

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PMID: 25496309
DOI: 10.4161/15384101.2014.987619

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