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Article

p62/SQSTM1 Accumulation Defines an Epithelial-Mesenchymal Transition (EMT)/Twist1-Associated Infiltrative Phenotype in Pancreatic Neuroendocrine Tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2026

Matsumoto Takashi, Yamamoto Takeo, Osajima Satoru, Nakanishi Yoshiyuki, Noguchi Shoko, Mizuuchi Yusuke, Murakami Masatoshi, Ueda Keijiro, Takigawa Ken, Shimo Masatoshi, Miyawaki Kohta, Kato Koji, Fujimori Nao, Nakata Kohei, Aishima Shinichi, Oda Yoshinao

Abstract excerpt

Pancreatic neuroendocrine tumors (PNETs) lack clinically validated biomarkers for risk stratification and treatment selection. p62 (also known as SQSTM1)-a multifunctional adaptor protein degraded by autophagy-has been associated with adverse outcomes, but its correlation with invasion and metastasis in PNETs remains unclear. We retrospectively analyzed 194 PNETs resected between January 1994 and December 2022....

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Identifiers

PMID: 41967709
DOI: 10.1016/j.modpat.2026.101001

Genes

SQSTM1
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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p62/SQSTM1 Accumulation Defines an Epithelial-Mesenchymal Transition (EMT)/Twist1-Associated Infiltrative Phenotype in Pancreatic Neuroendocrine Tumors.PMID 41967709Read ↗

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