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Article

p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis

11 Sept 2017

Abstract excerpt

The signalling adaptor p62 is frequently overexpressed in numerous cancer types. Here, we found that p62 expression was elevated in metastatic breast cancer and its overexpression correlated with reduced metastasis- and relapse-free survival times. Analysis of p62 expression in breast cancer cell lines demonstrated that high p62 expression was associated with the invasive phenotypes of breast cancer. Indeed,...

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PMID: 28968743
DOI: 10.1093/carcin/bgx099

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