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Article

p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA

27 Jun 2016

Abstract excerpt

populations and side population cells. Indeed, short-hairpin RNA (shRNA)-mediated knockdown of p62 impaired breast cancer cells from self-renewing under anchorage-independent conditions, whereas ectopic overexpression of p62 enhanced the self-renewal ability of breast cancer cells in vitro. Genetic depletion of p62 robustly inhibited tumor-initiating frequencies, as well as growth rates of BCSC-derived tumor...

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PMID: 27345399
DOI: 10.1038/onc.2016.202

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