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Article

SNPs and taxane toxicity in breast cancer patients.

Pharmacogenomics - 1 Jan 2014

Bosó Virginia, Herrero María José, Santaballa Ana, Palomar Laura, Megias Juan E, de la Cueva Helena, Rojas Luis, Marqués María Remedios, Poveda José Luis, Montalar Joaquin, Aliño Salvador F

Abstract excerpt

AIM: In order to identify genetic variants associated with taxanes toxicity, a panel with 47 SNPs in 20 genes involved in taxane pathways was designed. PATIENTS & METHODS: Genomic DNA of 113 breast cancer patients was analyzed (70 taking docetaxel, 43 taking paclitaxel). RESULTS: Two SNPs associated with docetaxel toxicity were identified: CYP3A4*1B with infusion-related reactions; and ERCC1 Gln504Lys with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25495407
DOI: 10.2217/pgs.14.127

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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