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Article

Association of CYP1B1 with hypersensitivity induced by taxane therapy in breast cancer patients.

Breast cancer research and treatment - 1 Nov 2010

Rizzo Roberta, Spaggiari Federica, Indelli Monica, Lelli Giorgio, Baricordi Olavio R, Rimessi Paola, Ferlini Alessandra

Abstract excerpt

Taxanes represent a group of anticancer drugs with a wide range of activity against breast cancer. Therapy side effects include haematologic toxicity (neutropenia, leucopenia), peripheral neuropathy and hypersensitivity, and demonstrate inter-individual variations. Since it is known that three genes are implicated in taxane turnover, namely ABCB1 in the transport, CYP2C8 in the metabolism and CYP1B1 in the...

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Share to Antineoplastic Agents, Phytogenic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20632082
DOI: 10.1007/s10549-010-1034-5

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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