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Article

Single nucleotide polymorphisms to predict taxanes toxicities and effectiveness in cancer patients.

The pharmacogenomics journal - 1 Aug 2021

Demurtas Sara, La Verde Nicla, Rota Selene, Casazza Giovanni, Montrasio Cristina, Cheli Stefania, Cona Maria Silvia, Dalu Davide, Fasola Cinzia, Ferrario Sabrina, Filipazzi Virginio, Gambaro Anna, Tosca Nicoletta, Clementi Emilio

Abstract excerpt

Taxanes are used in the treatment of several solid tumours. Adverse events (AEs) might be influenced by single nucleotide polymorphisms (SNPs) in genes encoding proteins responsible for pharmacokinetic and pharmacodynamic. In this prospective, monocentric, observational study we explored the effect of SNPs in the main genes involved in taxanes metabolism and transport, on toxicity and efficacy in 125 patients...

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PMID: 33649523
DOI: 10.1038/s41397-021-00227-7

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