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Article

Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes.

Anticancer research - 1 May 2017

Angelini Silvia, Botticelli Andrea, Onesti Concetta Elisa, Giusti Raffaele, Sini Valentina, Durante Valeria, Strigari Lidia, Gentile Giovanna, Cerbelli Bruna, Pellegrini Patrizia, Sgroi Valentina, Occhipinti Mario, DI Pietro Francesca Romana, Rossi Alessandro, Simmaco Maurizio, Mazzuca Federica, Marchetti Paolo

Abstract excerpt

BACKGROUND: Taxanes are widely used to treat breast cancer patients. Taxanes are metabolized in human liver by the cytochrome CYP3A and are substrate of ATP-binding cassette multidrug transporters ABCB1. Single-nucleotide polymorphisms (SNPs) in genes involved in taxanes' metabolism could affect the inter-individual variability in reported toxicities. MATERIALS AND METHODS: In this retrospective study, 152 women,...

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Identifiers

PMID: 28476838
DOI: 10.21873/anticanres.11610

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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